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產(chǎn)品編號 |
英文名稱 |
CAS號 |
包裝 |
|
Y3592 |
Emodin |
518-82-1 |
可根據(jù)客戶要求訂制 |
英文名稱：Emodin
CAS號：518-82-1
分析標準品，≥96.0% (HPLC)
分子式 C15H10O5 分子量270.24
基本信息:
密度 1.583
熔點 256-257°C
存貯條件 儲存溫度 2-8°C
描述
產(chǎn)品介紹 溶于乙醇，略溶于乙醚、氯仿、苯，不溶于水。溶于苛性堿水溶液、碳本酸鈉水溶液，氨溶液中顯櫻紅色。
別名 大黃素 ;朱砂蓮甲素,1,3,8-三羥基-6-甲基蒽醌;1,3,8-Tri-hydroxy-6-methyl-anthra-quinone 6-Methyl-1,3,8-tri-hydroxy-anthra-quinone Emodol Frangula-emodin
生化機理
Description:
IC50 Value: observed at 72 hr were as follows: 66.9 uM, Hep3B cells; 74.36 uM, HepG2 cells; and 101.5 uM, Huh7 cells [1].
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Emodin exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.
in vitro: At 6h after emodin treatment, the levels of GDF15, CYP1A1, CYP1B1, and CYR61 were upregulated [1]. Emodin increased the resting tension of gallbladder smooth muscle strips and inhibited voltage-dependent K(+) current in a dose-dependent manner. When 10 microM emodin was applied to gallbladder smooth muscle cells for 3-6 min., the amplitude of voltage-dependent K(+) current was decreased by 31.5 +/- 0.5% at +40 mV, and this inhibitory effect mostly recovered after washout [2].
Clinical trial: N/A
應(yīng)用 抑制NF -κB活化及粘附分子的表達。酪蛋白激酶2（CK2的）抑制劑.
熔點 256-257°C
存貯條件 儲存溫度 2-8°C
描述
產(chǎn)品介紹 溶于乙醇，略溶于乙醚、氯仿、苯，不溶于水。溶于苛性堿水溶液、碳本酸鈉水溶液，氨溶液中顯櫻紅色。
別名 大黃素 ;朱砂蓮甲素,1,3,8-三羥基-6-甲基蒽醌;1,3,8-Tri-hydroxy-6-methyl-anthra-quinone 6-Methyl-1,3,8-tri-hydroxy-anthra-quinone Emodol Frangula-emodin
生化機理
Description:
IC50 Value: observed at 72 hr were as follows: 66.9 uM, Hep3B cells; 74.36 uM, HepG2 cells; and 101.5 uM, Huh7 cells [1].
Emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a naturally occurring anthraquinone present in the roots and barks of numerous plants, molds, and lichens, and an active ingredient of various Chinese herbs. Emodin exerts antiproliferative effects in cancer cells that are regulated by different signaling pathways.
in vitro: At 6h after emodin treatment, the levels of GDF15, CYP1A1, CYP1B1, and CYR61 were upregulated [1]. Emodin increased the resting tension of gallbladder smooth muscle strips and inhibited voltage-dependent K(+) current in a dose-dependent manner. When 10 microM emodin was applied to gallbladder smooth muscle cells for 3-6 min., the amplitude of voltage-dependent K(+) current was decreased by 31.5 +/- 0.5% at +40 mV, and this inhibitory effect mostly recovered after washout [2].
Clinical trial: N/A
應(yīng)用 抑制NF -κB活化及粘附分子的表達。酪蛋白激酶2（CK2的）抑制劑.
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