英文名稱：(-)-Epicatechin gallate  
CAS號：1257-08-5
分析標(biāo)準(zhǔn)品,≥98%  
分子式 C22H18O 分子量442.37  
  

基本信息:

敏感性   對熱敏感
密度  1.8
溶解性   Soluble in water (5 mg/ml) with heat and sonication as needed, yielding a clear, colorless solution, ethanol (~1 mg/ml), methanol (sparingly), DMSO (~10 mg/ml), and DMF (~14 mg/ml).
存貯條件   儲(chǔ)存溫度2-8℃
描述  
別名   ;(-)-cis-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol 3-gallate; (-)-cis-3,3′,4′,5,7-Pentahydroxyflavane 3-gallate; (-)-Epicatechin-3-O-gallate
生化機(jī)理   (-)Epicatechin gallate is a polyphenol apoptosis inducer in tumor cells commonly found in green tea. Studies suggest that (-)Epicatechin gallate causes anti-proliferative and anti-inflammatory effects on pancreatic ductal adenocarcinoma cells. Alternate studies show that (-)Epicatechin gallate can suppress H2O2-induced genotoxicity in vitro in C6 astroglial cells. In contrast at high concentrations polyphenols are shown to reverse the genoprotective effects that they produce at low concentrations. Furthermore, (-)Epicatechin gallate can inhibit the development of mouse blastocysts via apoptosis. Studies indicate that (-)Epicatechin gallate binds to the cell membrane in methicillin-resistant Staphylococcus aureus which decreases the fluidity of the bilayer and induces changes in gene expression.
應(yīng)用   An antioxidant investigated as an adjunct treatment of some methyicillin resistant bacteria.